New study finds chemotherapy causes cancer to spread

There are two types of cancer treatment:

  • Local therapy: Treatments directed at the cancerous anatomic areas, such as surgery, radiation therapy, and hyperthermia therapy.
  • Systemic therapy: The use of drugs, introduced into the blood stream, and therefore in principle is able to address cancer at any anatomic location in the body, e.g., hormone therapy and chemotherapy.

Chemotherapy is a type of systemic treatment for cancer which uses cytotoxic drugs, i.e., intracellular poisons, to shrink cancerous tumors by inhibiting mitosis, the process of cell division, eventually leading to cell death. The problem is the cytotoxic drugs don’t just kill cancer cells but also damage normal cells, especially cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss).
But a new study has found something even worse and truly perverse about chemotherapy: Although it shrinks cancerous tumors, chemotherapy actually spreads (or metastasizes) cancer throughout the patient’s body.
The team of 16 scientists — led by Dr. George S. Karagiannis, a post-doc at the Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York — published their findings, “Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism,” in the peer-reviewed journal, Science Translational Medicine, vol. 9, issue 397, July 5, 2017.
Although the study was conducted on breast cancer, logically the findings should apply to other cancers as well, especially in view of the fact that breast cancer is one of the most common types of (cancerous) tumors.

malignant breast cancer cells


Karagiannis et al. focused their study on a group of cells called tumor microenvironment of metastasis (TMEM), which serve as gateways for cancerous tumor cells to enter the vasculature or circulatory system.

The scientists discovered that, in addition to killing tumor cells, chemotherapy treatment can increase the amounts of TMEM, leading to increased intravasation — the entrance and circulation of foreign material (cancerous cells) into the bloodstream.
Here’s the article’s Abstract:

Breast cancer cells disseminate through TIE2/MENACalc/MENAINV-dependent cancer cell intravasation sites, called tumor microenvironment of metastasis (TMEM), which are clinically validated as prognostic markers of metastasis in breast cancer patients. Using fixed tissue and intravital imaging of a PyMT murine model and patient-derived xenografts, we show that chemotherapy increases the density and activity of TMEM sites and Mena expression* and promotes distant metastasis. Moreover, in the residual breast cancers of patients treated with neoadjuvant paclitaxel after doxorubicin plus cyclophosphamide, TMEM score and its mechanistically connected MENAINV isoform expression pattern were both increased, suggesting that chemotherapy, despite decreasing tumor size, increases the risk of metastatic dissemination. Chemotherapy-induced TMEM activity and cancer cell dissemination were reversed by either administration of the TIE2 inhibitor rebastinib or knockdown of the MENA gene. Our results indicate that TMEM score increases and MENA isoform expression pattern changes with chemotherapy and can be used in predicting prometastatic changes in response to chemotherapy. Furthermore, inhibitors of TMEM function may improve clinical benefits of chemotherapy in the neoadjuvant setting or in metastatic disease.

*Note: “Mena expression” refers to the Mena protein, a key potentiator and modulator of cellular migration and, therefore, is a prometastatic factor.

The scientists do have one piece of good news: They found that a drug called rebastinib can interfere with TMEM activity and help overcome chemotherapy’s increased risk of cancer cell metastasis or dissemination.
See als0:

~Eowyn

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[…] Source: New study finds chemotherapy causes cancer to spread | Fellowship of the Minds […]

TrueDan
TrueDan
3 years ago

This study pertains to cytotoxic drugs, i.e., intracellular poisons, that kill cancer cells but also damage normal cells, . But does it pertain to the cytostatic drugs, i.e. targeted therapy drugs, which are not poisons but merely inhibitors of mitosis of specific types of cells, e.g. only specific types of cancer cells? An example of the cytostatic drugs is sutent (sunitinib malate) which works by blocking the action of the abnormal proteins that signal cancer cells to multiply and that call for additional blood supply to develop to feed the cancer cells.

kommonsentsjane
3 years ago

Reblogged this on kommonsentsjane and commented:
Reblogged on kommonsentsjane/blogkommonsents.
For your information.
kommonsentsjane

Alma
Alma
3 years ago

God helps us all, I am able to say that twelve years ago I had chemo, indescribable, it is Purgatory on Earth. I

Diane Wilson
3 years ago

We knew this. Chemo is poison; part of the depopulation program and a way for doctors to make a lot of money!

Auntie Lulu
Auntie Lulu
3 years ago

Yet, Big Pharma is no doubt raking in the big bucks selling the chemo drugs. I wonder if doctors will change how they are doing things in light of this finding.

truckjunkie
truckjunkie
3 years ago
Reply to  Auntie Lulu

Their thinking is,no doubt, “Is there a reason we SHOULD?”

Auntie Lulu
Auntie Lulu
3 years ago
Reply to  truckjunkie

truck . . . I thing you called that correctly! Why should they, when they can rob the public blind by continuing precisely what they are doing.

MomOfIV
MomOfIV
3 years ago

chemotherapy is a toxic concoction derived from mustard gas in WW1…and has been very profitable for the chemical/pharmaceutical industries for over a century.
The first patient died 6 months after being given the chemicals by a doctor named Haddow in 1942…..yet it was pursued anyway and has come to be part of the front-line in the battle for “treating” cancer.
Those who survive are very fortunate, because most do not. I believe more people have died from chemo than all the wars combined.
https://www.chrisbeatcancer.com/how-effective-is-chemotherapy/

marblenecltr
3 years ago

Reblogged this on necltr and commented:
A posting most worthy of attention.

Josh
Josh
3 years ago

I’ve long held that chemo helped destroy the ability for the immune system to function. I view the immune system as key to fighting everything from virii to cancer. I mean, as many cells as the human body produces over a lifetime, some percentage has to be mutant and it’s the immune systems job to find these and eliminate them. The almighty designed healing and maintenance into us, I suspect chemo and radiation defeats healing.

Josh
Josh
3 years ago

Oops forgot to mention some suspect cancer may be caused by virii, especially that found in vaccines.

truckjunkie
truckjunkie
3 years ago

A few years ago I remember hearing that Cancer was created by the US Government to eliminate a certain group of people (?),but at the time I wasn’t paying much attention;I knew,back then,that the US Government would NEVER do something like THAT. I’m not so gullible now….

Auntie Lulu
Auntie Lulu
3 years ago
Reply to  truckjunkie

truck . . . “I knew back then, that the US Government would NEVER do something like THAT. I’m not so gullible now …” Sounds like there are a whole lot of us in the same boat . . . the age of innocence is over for many of us!

Alma
Alma
3 years ago

Well, if the government wanted to eliminate people, what happened? Big mistake, I’m still hanging around!

truckjunkie
truckjunkie
3 years ago
Reply to  Alma

I’m not sure you’re in their target zone,nor are most of us. Besides-remember-this is the US Government we’re talking about,they RARELY get anything right the first time. (sarc) If I remember correctly,they wanted to eliminate select Minorities,Blacks in particular. They also monkeyed with Venereal Diseases in similar parameters back around the end of WW-II. (Don’t kill the Messenger.) I wish I could find the article this was mentioned in,but as I said,at the time I didn’t give it any credibility,so I wasn’t paying close attention. If anyone can shed more light on this,please feel free to correct me. Apparently their… Read more »

truckjunkie
truckjunkie
2 years ago
Reply to  Dr. Eowyn

THAT is what I was referring to!

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[…] Republished with permission Fellowship of the Minds […]

Christine Watts C.
3 years ago

One of my late girlfriends had breast cancer, and they put her on chemo–it was so bad at one point that, when she found out that the drugs given to her were in and of themselves poison, she decided to stop the chemo. She had been suffering like a dog from those drugs, and spent most of each day alone at home, being so sick she almost couldn’t get off the couch. She was so desperate, especially since no one was at home to help her get through each day. Finally, when she found out what she did about the… Read more »

MomOfIV
MomOfIV
3 years ago

I’m so sorry to read about your friend’s passing. I had a friend who died this past December after taking chemo AGAIN because her cancer resurfaced. She was insistent on listening to her oncologist (who reap enormous profits from chemo through bigpharma) and family to undergo chemo again. She trusted the doctor who was profiting from her illness. Those who survive chemo are very fortunate indeed (God bless them), yet they have a high recurrence rate because the chemo kills off cancer cells and immune cells…but it’s the Mother line of the cancer cells (cancer stem cells) that usually give… Read more »

truckjunkie
truckjunkie
3 years ago

My younger Sister had a Cancer on her chest for probably 15 years from the time her company Physician found it,did the biopsy and tried to get her to agree to surgery and a range of Cancer treatments;she refused. From then on,she knew about it but never sought medical help,never talked about it,never got treatment of it. 15 years on,she died-of a subdural hematoma. The autopsy showed the Cancer had spread very little in 15 years. Ironic,huh?

stevenbroiles
3 years ago

Our late landlady, “Ma,” as we used to call her, died of breast cancer last year. Her daughter made the cannabis oil after acquainting herself with the work of Rik Simpson. “Ma” had beaten cancer some 20 or more years earlier, and she was convinced that cannabis oil had been the answer the first time around. Sadly, it did not work when her cancer returned. I knew a woman, Maureen, from my neighborhood cab driving days in Ridgewood, Queens. She went the chemo-radiation route. She was one tough bird: She fought like a lion for about eight years. In the… Read more »

Glenn47
Glenn47
3 years ago
Reply to  stevenbroiles

Excellent comments Steve. I have done lots of reading because of some health issues, and I came across some of the same info you have. If you have ever taken antibiotics in your life, there is a chance you could have a yeast/fungus overload. Many people in the field do belive cancer is a fungus. There is a simple home test anyone can do to find out. I also found out and now use Oxygen drops. Which help me utilize my body’s oxygen better. Also we can take a home test for our PH. Most people will find themselves with… Read more »

Christine Watts C.
3 years ago

Great responses from you all–and, that’s some bad news for me, about the antibiotics–as a child I was so sickly, and if penicillin had not been invented by the time I’d needed it, in the early 1950’s, I know I wouldn’t be here now–I took it until I became allergic to it, then was switched to ‘sulfa drugs’, then from there to erythromycin type antibiotics–they pulled me through tons of tonsillitis, and pneumonia, eye infections, ear infections, bronchitis, and so forth, up until I was around 18–that’s when I moved away from the area I grew up in, in California,… Read more »

jeanelane
jeanelane
3 years ago

There is a 3rd type of cancer treatment, alternative therapies, of which there are many. But I am sure you are talking about M.D.-approved treatments. After surgery, before I was “in the know”, I am following alternative therapies. The percentages the oncologist quoted were not good enough for me to live in misery for the 5-year survival. I’m 2.5 years and thriving without poison or burning.

lophatt
lophatt
3 years ago
Reply to  jeanelane

I am approximately one and one-half years into mine. I did elect radiation and chemo. While I don’t trust the medical establishment, I did not want to “roll the dice” either. I actually lost friends over this.
All I will say is that it is very easy for those not facing cancer to criticism a person’s choice. So far, in my case, it has worked. I hope they come to understand its true nature and develop better treatments for it.